GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2143950 | 1 | rs57075379 | chr14:35577801 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.99 | 2.76E-6 | Atopic dermatitis |
| THYM | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | EFCAB5 | chr17:28256874-28435469:+ | 0.32 | 4.3 | 4.2E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9815354 | 1 | rs57479675 | chr3:41798038 | ULK4 | chr3:41288091-42003660:- | 1 | 10.7 | 5.35E-18 | Diastolic blood pressure |
| THYM | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | CYP2D6 | chr22:42522502-42526883:- | -0.69 | -7.37 | 6.15E-11 | Cognitive function |
| THYM | cis | rs60843830 | 1 | rs57542652 | chr2:228088 | SH3YL1 | chr2:218138-264810:- | -0.3 | -4.19 | 6.3E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | CYP2D6 | chr22:42522502-42526883:- | -0.72 | -7.77 | 9.19E-12 | Cognitive function |
| THYM | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | CYP2D6 | chr22:42522502-42526883:- | -0.72 | -7.76 | 9.45E-12 | Cognitive function |
| THYM | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | CYP2D6 | chr22:42522502-42526883:- | -0.69 | -7.37 | 6.15E-11 | Cognitive function |
| THYM | cis | rs494003 | 1 | rs578056 | chr11:65514874 | SNX32 | chr11:65601410-65621170:+ | 0.41 | 4.48 | 2.05E-5 | Systemic lupus erythematosus |
| THYM | cis | rs1875620 | 1 | rs57961801 | chr9:91563458 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs614226 | 1 | rs580016 | chr12:120933977 | PRKAB1 | chr12:120105757-120119428:+ | 0.45 | 4.3 | 4.12E-5 | Type 1 diabetes nephropathy |
| THYM | cis | rs2243480 | 1 | rs58062456 | chr7:65394852 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs477692 | 1 | rs580745 | chr10:131414401 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs2077224 | 1 | rs58130263 | chr11:62194100 | ASRGL1 | chr11:62104774-62160885:+ | -0.29 | -4.41 | 2.74E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs583583 | 1 | rs583583 | chr1:147083114 | ACP6 | chr1:147119168-147142634:- | 0.51 | 5.47 | 3.58E-7 | Schizophrenia (negative symptoms) |